Concomitant use of lisinopril reduces the effect of aspirin on bleeding

To determine the Lisinopril and Aspirin interaction through their concurrent effect on bleeding in adult male rabbits. Twenty four healthy adult male rabbits were used. Bleeding time of each animal was determined by Duke's Method. They were divided randomly in three groups containing equal number of animals into Control, Aspirin, Lisinopril and Combination groups. After oral administration of the drug[s], the bleeding time of the animals was again determined by same method. Prolongation of bleeding time was significant [p<0.05] in Aspirin and combination groups but insignificant [p>0.05] in Lisinopril group after 1 hour. It was significant [p<0.05] in Aspirin and Lisinopril groups but insignificant [p>0.05] in Combination group after 24 hours. This change was observed after 48 hours too. Concurrent use of Lisinopril reduces the effect of Aspirin on Bleeding after a certain time period

Standardization of herbal formulations: an overview

The herbal system of medicine has gained worldwide importance due to its safety and efficacy considerations. Herbal medicines have been used for treating various diseases since ancient times. The present article deals with the importance and method of standardization of herbal medicines in order to ensure their purity, safety and efficacy. A detailed introduction regarding various aspects of the herbal system of medicine and methods of achieving quality of herbal medicine has been presented The various quality control methods recommended by World Health Organization have been described. Effort has also been made to focus on the physical, chemical and biological evaluation to achieve a high standard of quality for herbal medicine

Antifungalactivity of cedrus deodara root oil against various fungal isolates

Antifungal activity of Cedrus deodara root oil against Aspergillus niger, Aspergillus flavus, Fusarium solani, Fusarium oxysporum, Rhizoctonia solani and Macrophomina phaseolina has been investigated using disc diffusion and well method. The maximum zone of inhibition of 6 mm was noted for Rhizoctonia solani for oil concentrations of 160 and 170 microg/disc while only 5 mm for 100, 120 and 140 microg/disc, respectively by disc diffusion method. No significant response has been observed against Fusarium solani, Fusarium oxysporum, Macrophomina phaseolona, Aspergillus niger and Aspergillus flavus. However, Aspergillus flavus showed maximum zone of inhibition of 8 mm for 210 microg and 7 mm for the concentration of 190 microg using well method where as the oil did not show any response against Aspergillus niger using well method

Constituents of garlic [allium sativum] and their efficacy in diabetes mellitus

Diabetes affects a large number of populations worldwide and the prevalence of this disease is rapidly increasing

Despite the availability of allopathic medications for diabetes, traditional remedies are desirable and are currently being investigated. Garlic [Allium sativum] has been reported to have antidiabetic activity. Evidences suggest that garlic has antioxidant, anti-inflammatory and antiglycative properties due to which it plays an important role in preventing diabetes progression and the development of diabetes-related complications. Large scale clinical studies with diabetic patients have been carried out to confirm the usefulness of garlic in the treatment and prevention of this disease. This article briefly reviews on the above stated subjected and the papers have been collected from internet resources including Pubmed, American Journal of Medicine, New England Journal of Medicine, Google Scholar and Journal of Medicinal Plant Research

Study of alteration of adrenergic receptor response by chronic use of lisinopril: an ACE inhibitor

Unpredictable outcomes of life saving drugs have been seen in patients who receive different cardioselective drugs for longer periods. Many studies have been conducted to explore these responses. This study shows the down regulation of adrenergic receptors due to chronic use of Lisinopril, an ACE inhibitor as a cause of poor response of adrenaline. Langendroff's technique was used. The data obtained from ten rabbits shows that effective dose of Lisinopril [10mg/kg daily orally] reduces the inotropic and chronotropic effects of adrenaline significantly [p<0.05].Therefore it is suggested to use higher doses of adrenaline in cardiac units in patients who have used therapeutic doses of Lisinopril for longer periods provided it is supported by clinical studies